Clinical Manifestations of Mast Cell Activation Syndrome By Organ Systems

Mast cell activation syndrome (MCAS) is a chronic multisystem illness of general themes of inflammation ± allergic-type phenomena ± abnormalities in growth/development in potentially any tissue. Mast cells produce and release, under a variety of circumstances, a very large number of potent molecular signals generically called mediators, and each mast cell mediator can bring about a wide variety of effects in a very wide variety of tissues, organs, and systems throughout the body, leading to a situation where inappropriate mast cell mediator production/release can result in an array of clinical problems, and yet the problems suffered by one MCAS patient can be extremely different from the pr

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